The most comprehensive non-invasive prenatal test (NIPT) for detecting fetal chromosomal abnormalities is currently the MaterniT21 PLUS TM Test. The only clinic in the UK to offer the MaterniT21 PLUS TM Test in pregnancy is The Medical Chambers Kensington. The MaterniT21 PLUS TM Test is not only the most comprehensive. It also has the lowest failure to get a result rate. This is when there is not enough of the baby's DNA in the mother's blood, a rare occurrence with this test. And it currently has the fastest turnaround time at 5 calendar days from arrival of the blood sample in the laboratory.
MaterniT21 PLUS TM tests for:
- Additional chromosomes 21, 18, 13 (linked with Down syndrome, Edwards syndrome and Patau syndrome)
- Gender (inspecting the X and Y chromosomes)
- 22q deletion syndrome (DiGeorge)
- 5p (Cri-du-chat syndrome)
- 15q (Prader-Willi/Angelman syndromes)
- 1p (1p36 deletion syndrome)
- Trisomy 16
- Trisomy 22
The MaterniT21 PLUS TM test currently has the fastest turnaround time at 5 calendar days from arrival of the blood sample in the laboratory. Of all NIPT prenatal tests it has the lowest failure to get a result rate (this is when there is not enough of the baby's DNA in the mother's blood, a rare occurrence with this test).
Who is the MaterniT21 PLUS TM test for?
You may be advised to have the MaterniT21 PLUS TM test if your specialist considers that your baby is at higher than normal risk of carrying a chromosomal abnormality. There may be a number of reasons for this; calculation of heightened risk may be linked with maternal age, family history, ultrasound scan results or results from a standard pregnancy blood test.
MaterniT21 PLUS TM : What to expect
The test can be carried out from week 10 of pregnancy, and is performed by taking a blood sample from a vein in your arm. Your specialist prenatal doctor will discuss the test with you in detail and you will have time to ask questions and talk through any concerns you have. We send your blood sample to Sequenom Laboratories in San Diego USA and the results are back with us within 5 calendar days of arrival of the blood sample in the laboratory.
We will call you with the results as soon as we receive them and we will send you a copy of your report. Our specialist prenatal doctor will also review the results before sending a report to your doctor.
The MaterniT21 PLUS TM test does not replace the need for the 12-week Nuchal scan, which allows close inspection of your baby's anatomy to give information the blood test cannot provide.
How does MaterniT21 PLUS TM work?
The MaterniT21 PLUS TM test uses a maternal blood sample to analyse the chromosomes in cell-free DNA from the baby that circulates in the mother's blood. This test provides more information on chromosomes than any other test available, including information on:
- the three most common trisomies linked with birth defects (Trisomy 21, 18 and 13)
- defects linked to abnormal sequencing of the sex-chromosomes
- rarer chromosome abnormalities
It offers a positive or negative result, rather than a risk factor as other tests do. The rates of non-reportable results, insignificant findings and false-positive results are extremely low, making this the most useful test available and reducing the likelihood of prolonged uncertainty or the need for inveasive testing where a result is uncertain.
Follow this link for more information on the MaterniT21 PLUS TM test.
Accuracy of results with MaterniT21 PLUS TM prenatal test
With over 130,000 clinical trials to date, the MaterniT21 PLUS TM test has proved extremely accurate (for instance with greater than 99.9% detection of Trisomy 18; and 99.1% detection of Trisomy 21). It is important to note however that, as with every other prenatal test, results can never be considered 100% accurate; and some abnormalities can go undetected even with the most up-to-date diagnostic procedures.
Your doctor will talk you through the results in detail. If a positive result is indicated, you may wish to have a further invasive test either amniocentesis or CVS. We understand that this is a sensitive time for parents, and will always do our best to answer questions, and provide a supportive and unhurried environment.